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In summary, when tested as single compounds, fungal VOCs affected A. thaliana in positive, negative or neutral ways.
PAHs generally occur as complex mixtures (for example, as part of combustion products such as soot), not as single compounds.
We further investigated the effects of BRO, thyme extract as well as single compounds of thyme extract on enzymatic activity of 5-lipoxygenase (5-LO).
Consumers should also be informed that the vast majority of natural cosmetic products contain allergenic fragrance compounds, either as single compounds added or as natural constituents of various natural substances.
Our studies are well-based in our knowledge of their performance as single compounds.
Three phenols, BPA, benzophenone-3, and triclosan, were each above the LOD in at least 75% of study participants and were evaluated as single compounds in our analysis.
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However in another study, davanone as single compound showed only very weak in vitro activity against C. albicans[29].
As shown in Fig. 5a, 1.6 mg/mL Gardeniae Fructus contained approximately 0.5 mM geniposide, and the geniposide in the extract was hydrolyzed by free rBGLa to a similar pattern as single compound reaction (Fig. 4).
The fixed combinations of anticholinergics + SABA were frequently used in the Netherlands and Italy but not in the UK, where mostly anticholinergics were used as single compound.
Starting from the high-throughput screening platform dose response curves from both single compounds as well as their combinations were determined for a large panel of genetically annotated non-small cell lung cancer cell lines.
These observations need to be further scrutinized in studies on cellular, toxicological mechanisms involved in vivo /ex vivo using exposure of single compounds as well as mixtures reflecting the actual complex mixtures found in human serum.
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