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Therefore, data from multiple centers in Spain and Denmark are treated as single centers, whereas the centers from the UK, Germany, The Netherlands, Italy and Sweden are treated separately in our analyses.
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The bulk of worldwide clinical trials are of the non-multicenter variety, such as single center controlled or randomized-controlled clinical trials.
The study is designed as single center randomized controlled trial in which patients will be blinded for the allocated treatment.
Previous studies had several limitations, such as being conducted at single centers and usually having limited numbers of patients, although Dellit et al. evaluated 819 patients [ 19].
Limitations: 2 Retrospective trial was included and most of the trials included was designed as single-center study.
As single-center GWAS are usually underpowered, the standard strategy in the field is meta-analysis, the combination of results from multiple independent studies, increasing sample size and reducing false-positive findings.
If we think that large observational studies approximate 'the truth' as much as small single center studies, we need to recognize this in our classification systems.
As a limitation, this study was conducted as a single center study and endoscopies were performed by a single endoscopist and it is anticipated that the interpretation of digital chromoendoscopy findings are also subject to inter-individual variations.
Material and methods: This study was designed as a single center's (university hospital) experience.
As a single center, single arm intervention, generalizability is limited.
The trial is carried out as a single center trial at the University of Heidelberg, Department of Radiation Oncology in Germany.
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