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The salt cocktail prompted similar feelings of thirstiness in the young and old subjects, as well as similar changes in cerebral blood flow.
Moreover, as similar changes were not observed under fasting conditions, such changes were unlikely to be a predominant result of the disease per se.
Some common results were found, such as similar changes in transcriptional networks.
However, this increase in luciferase activity appears to be independent of the purine base as similar changes were seen with treatments containing dibutyryl cAMP.
These changes may represent a mechanical rather than a toxic effect as similar changes have been reported in the superior retina in silicone-filled eyes.
An enhancement of GABAAR function by the neurosteroid appears to be the likely mechanism underlying the observed anatomical rearrangement as similar changes in interneuron placement become apparent following postnatal exposure to the benzodiazepine, flunitrazepam (Grobin et al., 2004).
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This showed that the described chromatin remodeling occurs on other subtelomeres as well, as we observed similar changes upon senescence compared with the subtelomeres of 7q and 11q (Fig. S5 ).
In particular, a linear Notch pathway would predict that deletion of RBP-J [30], [75] would result in similar changes as would Notch blockade by γ-secretase inhibitors, or even by over-expression of dominant-negative (DN) MAML [78].
We have characterised the properties of the disc following enzymatic digestion which results in some similar changes as are seen in degeneration of the human intervertebral disc.
There is also some data on age-related changes that occur in the suprachiasmatic nucleus (SCN) in terms of unchanged neuron number with increasing age, which might lend support to the notion that the optic pretectal nucleus (OPN) (the nucleus which integrates the various afferent signals driving the pupil light reflex) might undergo similar changes as well [ 43].
As supporting evidence, similar changes were observed in VCaP/PSC27 and MDA-MB-231/HBF1203 tumors (not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com