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The phrase "as significant obstacles" is correct and usable in written English.
It can be used when discussing challenges or barriers that are important or noteworthy in a particular context.
Example: "The team faced several significant obstacles during the project, including budget constraints and tight deadlines."
Alternatives: "as major hurdles" or "as considerable challenges".
Exact(8)
The institute, a public policy and litigating organization based here, has filed lawsuits around the country attacking Blaine amendments, which stand as significant obstacles to expansion of the Ohio voucher program that the Supreme Court upheld last June.
Students overwhelmingly cited time spent online and with electronic devices as significant obstacles to sleep.
Although they could in principle be used systemically, proteolytic degradation and efficient peptide clearance pose as significant obstacles in the dynamic circulatory system.
The lack of availability of specific training, difficulties in being liberated from work, and distance to training locations were identified as significant obstacles in this regard.
A lack of understanding of the role of Child Support and lack of knowledge of regulations and legal financial responsibilities were also cited as significant obstacles to men's involvement.
Although participants recognised that an EHIS would address many of these problems and supported the idea of an EHIS, they cited resource limitations (lack of computers and technological support), overburdened staff, and computer literacy issues among staff as significant obstacles to the implementation of an EHIS.
Similar(52)
But even that isn't as significant an obstacle as it might appear to be.
The bill, which could come to a House vote as early as Friday, faces significant obstacles in the Senate.
And like me, they are women struggling to make a difference in their communities, as entrepreneurs, political candidates, and heads of non-profits, and as women who face significant obstacles towards full equality.
Ms. Gillibrand, who was twice elected to Congress from a mostly white and rural district stretching from Hudson to the Adirondacks, still faces significant obstacles as she seeks to be elected in her own right.
However, while Cyprus is now likely to remain in the eurozone, the country still faces significant obstacles as it attempts to recover from the crisis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com