The phrase "as significant difficulties" is correct and usable in written English.
It can be used when discussing challenges or obstacles that are considerable in nature.
Example: "The project faced as significant difficulties that delayed its completion."
Alternatives: "as considerable challenges" or "as major obstacles".
1– 4 Prevalence studies indicate that around 13.6% of children with Asperger syndrome (AS) suffer from clinically relevant anxiety 5 and up to 45% of adolescents with AS have significant difficulties with generalised anxiety, social anxiety or specific phobias.
Issues associated to teaching of gerontology were defined as the significant difficulties for acquisition of theoretical knowledge, technical skills, procedures, personal relationships, and autonomous learning during the teaching-learning process of gerontology.
The growing number of elderly people means more patients with multiple conditions - some of which, such as dementia, present significant difficulties in providing care and support.
But for humans, the situation is more complicated, as there are significant difficulties in obtaining reliable data on which to base an estimate of human ΔNdiet-body.
Literature scrutinized reveals that entrepreneurs need to engage in planning, as new ventures experience significant difficulties in finding a viable business model, and they often need to adapt their initial business plans (Andries and Debackere 2007).
"The changing regulations in respect of offshore pensions have caused him significant difficulties, as I am sure it must have for other overseas players in the UK, but fortunately for him an opportunity has arisen back home which will help him going forward.
People with diabetes are generally at a greater risk if they catch the flu, as it can pose significant difficulties with diabetes management.
The diffusive nature of light transport in turbid media such as biological tissues presents significant difficulties in image reconstruction problems and requires development of more sophisticated algorithms than those used in OPT.
As long as the court case stays unresolved, Silberfein predicted "significant difficulties and cost increases" in the bond financing.
We have encountered significant difficulties, such as probe cross-reactivity and non-specific product detection, using conventional methods, in assessing the specificity of Tβ4 knockdown as against a non-specific effect on its closest relative Thymosin beta 10 (Tβ10).
