Sentence examples for as showing copy from inspiring English sources

Three contigs (500 1,400 nt), estimated as showing copy numbers between 3 and 12, potentially encode proteins with high similarity to transposases/integrases, whereas another (copy number = 3 4) might encode a homolog of an LPXTG-motif protein cell wall anchor domain protein and a contig of approximately 900 nt (copy number = 2 3) potentially encodes an autolysin modifying protein.

As previously shown, copy number variants can have an impact on phenotypic variation mainly due to gene-dosage effects [ 80], and are often associated with disease susceptibility [ 38- 40, 81].

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The vast majority of these were described as regions that showed copy number variation (CNV) according to the databases included in the UCSC genome browser (Table 2), although these regions were not distinguished from other CNVs as containing tandem arrays.

In this study, we defined tumour-specific CNV regions as those which show copy number change in the tumour genome but do not overlap germline CNV regions identified in the genome of the matched normal tissue.

These genes are also proportionally over-represented at regions that show copy number variation as well as regions that show segmental duplications [ 25].

Moreover, at least some of the long microsatellites located within genes showed copy number variation, as demonstrated in several sets of ESTs apparently transcribed from the same gene (Additional file 4b).

For HP yeast genes, the altered gene dosage not only increases growth rate but, as we will show, copy-number reduction, as opposed to complete gene deletion, is sufficient to result in abnormal progression through the cell cycle, increased accumulation of DNA damage, and altered rates of apoptosis.

As shown, extra copies of PGC-1α conferred increased resistance to oxidative stress in mouse fibroblasts (Fig. 1A), in agreement with previous studies (Valle et al., 2005; St-Pierre et al., 2006).

Conversely, "false-reduced CNV regions" were defined as showing a loss in copy number, defined as a score of < 1.7, in the HPV+ cohort, or a gain in copy number, defined as a score of > 2.3, in the HPV- cohort.

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