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Thus, for data on which GHOST's AS is superior to MI-GRAAL's AS, the combination of MI-GRAAL's NCF and GHOST's AS represents a new superior method.
However, the definition of an early stage of AS represents a methodological problem because there are no validated classification or diagnostic criteria [ 6].
The aim of this study was to evaluate and compare thrombotic risk after THA between patients with AS and those with noninflammatory arthritis, osteoarthritis (OA), to clarify whether AS represents a risk factor to VTE following THA.
On one hand, the pathophysiological mechanism of disability in AS represents a very intriguing issue to be addressed since it provides new therapeutic opportunities in the management of these patients.
Nevertheless, although AS represents a key tool to control gene expression in higher organisms, the extreme flexibility and multilayer nature of its regulation render it error prone and susceptible to alterations that threatens the maintenance of cellular homeostasis.
Nevertheless, it is not possible to measure active Rho levels by conventional assays (like the Pull-down Activation Assay): the AS represents a very small proportion of the whole embryo, and even in the case that all the Rho protein is active (i.e. GTP loaded) in the AS of the foscrb Y10A embryos, we think that the other tissues of the embryo will mask the difference when processed for the assay.
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