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2014) can be understood as a consequence of the low-(N_e) population genetic environment of these organisms, which facilitates the evolution of new regulatory elements and the complexification of regulatory networks, as many of the intermediates in the process are either effectively neutral or maladaptive (Lynch 2007c) and are not as readily tolerated in organisms with large (N_e).
Similar(57)
Ectopic expression of EWS-FLI1 in undifferentiated hNCSC and their neuro-mesenchymal stem cell (hNC-MSC) progeny was readily tolerated and led to altered expression of both well established as well as novel EWS-FLI1 target genes.
Such behavior is perhaps more readily tolerated in music than in other fields of endeavor.
The evidence supports the view that failure is too readily tolerated.
He is delighted with his billet one where overnight guests are readily tolerated.
This might have been more readily tolerated had Mr Newman himself not been so roundly disliked by so many of Bankers' staff.
Also, it readily tolerated 3000 cycles of electrochemical testing and extreme mechanical deformation.
In contrast, mismatches on the downstream side of a ligation junction in duplex DNA (Fig. 6D) are more readily tolerated [31], [34].
Platinum(IV -based antIV -basedrugs might be less toxic anticancereadrugstolerated by normightells.
This is consistent with biological expectation: mutations, which can be disease-causing, are not readily tolerated in cancer proteins.
We predicted that the +F fish would be more readily tolerated by the unfamiliar dominant pair in the experimental tanks.
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CEO of Professional Science Editing for Scientists @ prosciediting.com