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Using microarray and in situ hybridization datasets we have produced a model of this network which contains over 600 genes, including numerous retinal disease loci as well as previously uncharacterized photoreceptor transcription factors.
Of the 2013 Unigenes, 807 were identified as previously uncharacterized.
Well-known, as well as previously uncharacterized infections continue to (re)emerge around the globe.
The algorithm was tested using an optimal, paired tumor/normal data set as well as previously uncharacterized pediatric malignant gliomas for which a normal reference set was not available.
Here, we compared genome sequences ranging from primitive aquatic to higher terrestrial species and described for the first time a number of novel UCEs present in primitive species as well as previously uncharacterized UCEs in human and fruit fly.
We demonstrated that incorporation of information about the activity profiles of transcription factors allows for a reliable identification of many known as well as previously uncharacterized regulatory interactions, which could not be achieved by methods solely relying on gene expression associations.
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In this regard, Stau1, a known RNA-binding protein implicated in both RNA stability and localization [ 22- 24], was shown in this work to regulate TP53 in an as yet previously uncharacterized way.
As reported previously, the purified F-BAR domain of Syp1 and BAR domain of Rvs161/ 167 (Reider et al., 2009; Youn et al., 2010), as well as the previously uncharacterized F-BAR domain of Bzz1, induced tubulation of PI 4,5 P2-containing vesicles.
We identified and characterized a novel alternate splice-isoform of Spire1 that contains KIND and WH2 domains common to all Spire proteins, as well as a previously uncharacterized unique 58 amino acid alternate exon sequence (ExonC).
Mass spectrometric analyses of the column eluates demonstrated the presence of Carma-1 as well as three previously uncharacterized adaptor proteins in B cells, one of which was the Trk-fused gene (Tfg), an adaptor protein containing PB1 and coiled-coil domains.
SNX9, SNX18 and SNX33 were all able to remodel liposomes into tubular membrane structures (Pylypenko et al, 2007; Haberg et al, 2008), as were the previously uncharacterized SNX4 and SNX8.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com