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However, structural studies of Map have demonstrated Map mimics the activation mechanism of RhoGEFs and is not a Cdc42 mimic as previous postulated [ 122].
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As previous authors postulated [ 14, 15], chamaeleonids are likely to have experienced transmarine dispersal over Mozambique Channel multiple times.
It is clear that societal response to environmental change is not as straightforward as postulated in many studies.
Hence on the basis of our findings, different features of the dopaminergic neurons are revealed, considering that they are not exclusively related to wakefulness as initially postulated, according to previous lesion studies [26], [27].
This result is in contrast to previous postulates predicting C559′ as first to dissociate, which were based primarily on the observation of Cd2+ complexed to the equivalent of C136, Y194, Y535′, and C558′ in the Bacillus MerA X-ray structure.
Previous work postulated that extrasynaptic NMDA receptors generate SICs because of their slow kinetics and block by NR2B subunit-specific antagonists such as ifenprodil (Fellin et al., 2004; Araque et al., 2014).
This empirical finding supports the existence of a corresponding hypothetical circle as postulated by previous studies, clinical experience and intuition.
Thus, the results indicate that ST-3 is not only involved in tumour formation, as it was postulated by previous studies [ 14], but additionally in tumour progression.
The results confirm the rapid radiation and burst of cladogenesis in the Triculinae, as postulated by previous authors [ 15, 21, 64], and suggest that the acceleration began around 6 Ma.
On the other hand, if as postulated in previous models (Lisman), turnover occurred by subunit exchange, the key step in protein turnover would be insertion of unphosphorylated (new) subunits into a previously activated holoenzyme.
Our findings suggest an additive effect of SCh as postulated by previous investigations in which the onset of an MH episode was significantly enhanced and the increase of serum creatine kinase was more pronounced after a combination of SCh and volatile anaesthetics [ 10, 19, 20].
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