According to the wide studies in this area, the substrate recognition, specifically supramolecular interactions, and the cooperativity between the catalytic sites and substrate-binding sites have been regarded as pivotal factors for designing an efficient artificial enzyme.
miRNAs have been recognized as pivotal factors in defining the specificity and sensitivity of post-transcriptional gene silencing.
26 Cognitive dissonance, denial and previous personal or vicarious experience have all been identified as pivotal factors in the relationship between adolescents' risk perception and risk behaviour.
TNF α and IL-6, as pivotal factors for myeloma, can be ideal targets for therapeutic purpose, either directly or by inhibiting interaction with BMSCs.
Expression and activity of the efflux transporters ABCB1 and ABCG2 have also been suggested as pivotal factors contributing to drug resistance by increasing the efflux of chemotherapeutic compounds in the setting termed "multidrug resistance".
Our data are in agreement with a recent study, which indicated both sediment particle size and the concentration of metals, including Fe and Zn, as pivotal factors in shaping the sediment's bacterial community [ 48].
These data sustain the role of RAS components in cardiac remodelling induced by Ang II, as well as the relation between mitochondrial dysfunction, altered cardiac metabolism [ 70] (e.g., downregulation of mitochondrial and lipid metabolism genes) [ 72], and the proteome as pivotal factors in cardiac pathological hypertrophy.
Time to develop team cohesion as well as PI training for members of the public and researchers were seen as pivotal factors in effecting meaningful PI: There needs to be a recognition that all sides have valuable contributions to make to research and that peoples' attitudes and beliefs, both researchers and the public, are valid and worthy of respect.
Beside promoter methylation of the O 6 -methylguanine-DNA-methyltransferase (MGMT) geffluxe efflux transporters ABCB1 and ABCG2 have been suggested as pivotal factors contributing to drug resistance, but the methylation of ABCB1 and ABCG2 has not been assessed before in GBM.
Shiite religious leaders, without even leaving their homes in Najaf, have already emerged as a pivotal factor in the deliberations at the Iraqi Governing Council in Baghdad.
