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As per the protocol of this study, small metastases localised in only one slice inevitably result in discordant findings.
Dose modifications or delays in study drug administration were allowed as per protocol.
Two consecutive shocks of 65 J were required as per protocol in the initial 13 patients.
Five patients (16%) who had a DLT were required as per protocol to be discontinued from study treatment.
After the exclusion of duplicates and studies not meeting the inclusion criteria, we obtained full text articles as per protocol.
The study ended as per the protocol.
As per protocol, this patient was removed from study due to grade 4 ALT.
Comparison of both analyses should have been performed as per-protocol analysis alone may distort the evidence [43].
Effects will be analysed primarily as intention-to-treat-analyses and additionally as per-protocol analyses.
Overall, 666 patients remained for final analysis and we refer to this group as the per protocol cohort.
This was cloned into pGEX-4T-2 expression vector, expressed as a GST tagged peptide, purified as per standard protocol and this fusion protein (206 aa) was used to raise antibodies in rabbits at Thermo Fischer/Open Biosystems, Rockford, IL, USA (Ring et al., 2002).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com