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Of these 95 were excluded as per pre-specified exclusion criteria (Fig. 1) and inability to sample patients for 2 months (September and October) due to logistic reasons.
In the clinical trial setting, Bayesian instruments based on the INLA approach can be applied as decision support to pre-specify a suitable final model for sensitivity analyses.
However, this association requires validation, and was not significant at P < 0.01 as we pre-specified for secondary analyses.
Greatest difference was found for the mental health sub scale (Effect Size 0.35, p = 0.17) As pre-specified in the research protocol we analysed sub-groups of participants.
No statistical comparisons of EQ-5D scores were conducted as none were pre-specified in the a priori statistical analysis plan.
Implementation of ≥6 best practices (quality index [QI] ≥6) was pre-specified as a desirable goal for keeping radiation exposure at a low level.
Our decision to pre-specify a fixed-effect as the primary analysis was taken to counter this limitation.
The CHIP-CE PRF ACHIP-CE PRFdomAchievement-specifiedomainhe primary HRQL outcome.
The CHIP-CE PRF ACHIP-CE PRFdomAchievement-specifiedomainhe primary HRQL measure.
This process, which was not pre-specified in the MUSIC protocol, was undertaken as a means of assessing the accuracy of the local readings.
We pre-specified the study's primary outcome to be CRF as measured by the BFI at follow-up.
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