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The remaining 464 patients were then randomised and received intervention as per allocated groups A (Pre-incision) or B (Post-incision).
On weeks 2, 4, 6, 8, 10 and 12, topotecan was administered by 96-h i.v. infusion as per allocated DL.
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At a tactical level, the available OR time is divided between the surgical subspecialties that are based on different criteria, such as the total cases per allocated block (i.e., historical utilization), hospital costs, gains per allocated block (i.e., financial criteria), the demand for services (i.e., the waiting list), etc.
On weeks 1, 3, 5, 7, 9 and 11, etoposide was administered orally per allocated dose level (DL) as 10 doses in 5 days with b.i.d.
The government and donors are programmed to respond without bias to disease A or B. They are set to allocate the same $ per DALY averted to disease A as is allocated to disease B during an epidemic, as long as there is no political lobbying.
On the visit day-4 and −7, MCH staff/study supervisor applied CHX using second and third type of container, respectively (as per the sequence allocated).
Per-protocol was defined a priori as an allocated TAC dressing having been in place for at least 24 hours.
Under the Medicare Advantage scheme, US providers such as ChenMed are allocated a national average of $9,600 £6,7000) per year per patient – compared with the estimated £4,000 annual cost for elderly patients in the UK with at least one long-term condition.
The intervention - 40 60 minutes per session, twice a week, for 12 weeks - started as soon as the patient was allocated to the IG.
All participants received powder or gel as allocated for their first round of ECV, so intention to treat analysis and per protocol analysis yielded identical results.
All women completed the study as allocated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com