We emphasize here that the restored antagonism was not due to recovering receptor ligand interactions at the mutation site (residue 876 on helix 11) but rather pushing helix 12 to adopt an antagonist-like conformation as our design rationale, the D-ring hypothesis, intended.
As explained earlier our rationale for this style of teaching was based on faculty experience both at SMRU [ 15, 16] and elsewhere, along with literature describing other similar projects successfully delivered in this style [ 19].
As shown so far, our rationale for focusing on animal metaphors has included the fact that we use metaphor to conceptualize ourselves as animals/non-animals in a variety of social, cultural, and political situations.
Our rationale is as follows.
Our rationale was as follows: Anecdotal reports in the literature suggest that sensitivity to toxic cations, including hygromycin B, is a characteristic of strains exhibiting alterations in K+ homeostasis.
Our rationale was as follows: (1) a fully human antibody is expected to have low immunogenicity, (2) IgG4 has a masking property, without depleting CD40 positive cells, such as B cells, DCs, macrophages, platelets, etc. and (3) IgG4 has low binding affinity for FC gamma receptors (FcγRs), which can cross-link the antibodies and induce agonistic activities 36.
Our rationale was as follows: (1) If indeed stress-inducible changes in hippocampal miR-132 and AChE cause long-lasting effects, miR-132 increases and AChE activity decreases should be observed in different stress models and even several days after the initiation of psychological stress.
In either case, these positions are every bit as biblically justified as citing Leviticus as your rationale for hating gays.
This announcement was surprising, as was her rationale.
As detailed in our theoretical rationale, geographic remoteness was a contextual factor of key interest in the xTEND project.
