Eye discharge, eye pain, foreign body sensation, photophobia and lacrimation as symptoms and redness (hyperaemia) and oedema (swelling), swelling of the eyelid, lacrimal-sac fluid reflux and keratitis as objective findings were classified into four levels and recorded as follows: notably severe, 3 points; marked, 2 points; obvious,1 point; and none, 0 points.
A combination regimen of cisplatin and gemcitabine was developed and compared with M-VAC, producing comparable efficacy results, and a reduction of side effects (most notably severe mucositis and infections, as well as alopecia) (Von Der Maase et al, 2000).
Notably, severe hepatotoxicity, as seen with ansamycin-based HSP90 inhibitors in GIST, did not occur.
FDCM patients with doubly heterozygous mutations show a notably severe phenotype as we could confirm in our study; this indicates that the double mutations had a dose effect.
The agency's report came as other signs of economic weakness were further revealed, notably severe drops in port calls and automotive production.
As with injury to the blood vessel wall, certain systemic disease states (notably severe infection and sepsis) result in expression of tissue factor (TF) on vascular cells.
Notably, severe erosion areas in 1975, 1958 and 1982 are all quite extensive.
Not only was his treatment notably severe, but the Department of Justice also aggressively pursued Risen, essentially threatening the journalist with imprisonment for refusing to disclose his source.
However, notably, severe anaemia (haemoglobin <500 g/l) at admission was not associated with mortality.
This rare genetic disorder is characterized by excessive lipid accumulation in multiple tissues and becomes clinically evident most notably as severe dilated cardiomyopathy.
Compared to MedianCD and SVCD normalization, the other normalization methods resulted in notably more severe degradation of the FDR.
