Additional point mutations or intragenic deletions of GLRA4 as well as functional studies are needed to further validate our hypothesis.
However, functional analyses such as loss-of-function and/or gain-of-function studies as well as localization analysis are needed to further analyze its potential functions.
Experiments designed to analyze whether senescent endothelial cells appear in the brain under specific circumstances, such as angiogenesis, are needed to further study the possible relation between senescence and the development of cavernous malformations.
Besides, this is just a retrospective study, and a validation group as well as an independent group is needed to further confirm our study results.
Independent molecular evidence, such as microRNAs or phylogenomic data on a similarly comprehensive and dense taxon sampling as used herein, will be needed to further test these hypotheses.
Additional studies examining other OS-related biomarkers, such as SOD and GSH-Px, are needed to further assess the NP-induced OS status in this system.
Bisphosphonates have been studied in respect to their effect on disease activity in AS, but their effects on fractures, BMD and the new bone formation in AS needs to be further investigated.
[C2.] Greenspan Vows to Keep Rates Low The Federal Reserve is prepared to hold interest rates low "for as long as needed" to stimulate further growth, the chairman, Alan Greenspan, said as he presented an upbeat economic forecast to a House committee.
E1 BUSINESS DAY C1-12 Fed to Keep Rates Low The Federal Reserve is prepared to hold interest rates low "for as long as needed" to stimulate further growth, said the chairman, Alan Greenspan, even as he presented an unexpectedly upbeat economic forecast to a House committee.
"Ask only if necessary: Are you now married (Probe as needed to code further): Now married, living with partner, widowed, divorced, separated, never been married, other (specify), don't know/refused".
