Sentence examples for as needed dosing from inspiring English sources

During weeks 24 52, patients in both groups received aflibercept if they met protocol-specified retreatment criteria and received a sham injection if retreatment was not indicated (3.9 SE 0.3 injections in the sham group and 2.7 SE 0.2 injections in the aflibercept group); after the first year, patients continued in an 1-year extension phase with as needed dosing.

Due in part to its off-label use in ophthalmology, bevacizumab has never been subjected to comparable controlled trials, but the recently reported Comparison of Age-related Macular Degeneration Treatment Trials demonstrated its near equivalency to ranibizumab with monthly dosing (8.0 letters vs 8.5 letters) and non-significantly poorer outcomes with as needed dosing (5.9 letters vs 6.8 letters).

The program had other elements that might be just as important as physical activity, including a shift away from continuous intravenous sedative and pain medications to "as needed" dosing.

Since patients from the VIEW studies receive as needed dosing (with treatment-free intervals not exceeding 3 months) after the first year and open label, as needed VTE after year 2, future data will better define the efficacy of less frequent, as needed dosing.

Although there is limited evidence that an as needed benzodiazepine dosing schedule could pose risks for patients, particularly in elderly people and those with substance use disorders, 35 36 we found no association between as needed dosing and risk of death from overdose compared with regularly scheduled dosing after adjustment for potential confounders.

Patients experiencing severe toxicity were permitted 1-week periods off treatment as needed; dose reduction to 25 mg was also permitted.

Previous reports have shown successful outcomes with bevacizumab treatment in patients with RVO following either an as-needed dosing schedule [ 15] or 3 monthly injections followed by as-needed dosing [ 19].

The CATT trial demonstrated that monthly injections of ranibizumab and bevacizumab had more favourable outcomes, compared to as-needed dosing, though this difference was small, on average.

A meta-analysis of 11 studies (6596 patients) that compared systemic safety in relation to different regimens (doses and frequencies) of ranibizumab treatment (but for age-related macular degeneration [AMD]) identified a possible relationship associated with monthly versus as-needed dosing for cerebrovascular accidents [ 42].

Appearing at Philadelphia's 30th Street Station, Vice President Joe Biden pitched the proposed infrastructure program as a needed dose of stimulus at a time when states are looking for cheap sources of jobs.

Our study subjects likely represent a highly motivated subgroup of families with type 1 diabetes who are more likely to closely monitor their children's blood glucose and give additional correction doses as needed.