Sentence examples for as major target from inspiring English sources

These endeavors were related to the amyloid cascade hypothesis which assumes that fibrillar Aβ is one of the key pathogenic hallmarks of AD [4-6], therefore, it has been depicted as major target for non-invasive diagnosing of AD.

Our analysis identified S17 and T21 in BMAL1 as major target sites for GSK3β- mediated phosphorylation.

Thus, the binding of extracellular Gal-4 to this complex or a tightly associated glycoprotein as major target implies that Gal-4 is capable of modulating central T cell functions.

Having demonstrated that Gal-4 homes in on CD3 or a tightly associated glycoprotein as major target, we hypothesized that Gal-4 modulates central T cell functions and went on to investigate the effect of Gal-4 on T cell activation and proliferation.

In particular, our results identify men and workers in manual occupations as major target groups for injury prevention in Estonia.

Bartonellae are mammalian pathogens that infect erythrocytes and vascular endothelial cells as major target cells (Dehio, 2004).

As a dwindling number of players in entertainment becomes responsible for ever more of the nation's cultural output, the remaining companies stand out as major targets, some analysts say.

Our results indicate that tumor-derived CRCL not only promotes the activation of dendritic cells, but also significantly fosters the function of macrophages that thus appear as major targets of this vaccine.

During the past decade, healthcare quality and patient safety have emerged as major targets for improvement.

These essential features should be viewed as major targets for theoretical interpretation and validation metrics of any basic MJO theory.

Since 2005, the China-based TNCs engaging in labour-intensive, environment-polluting, low value-added industries have been designated by the Chinese government as major targets for industrial restructuring (Yang 2012).