This genomic instability should arguably be regarded not as the main driving force of tumorigenesis, but as an adaptation to specific environmental conditions or, intriguingly, as a pleiotropic effect of mutations selected primarily for their effects on cell replication and/or death.
The advantage is that now this can be done with a minimal complexity approach —that is, adding as little complexity as possible in order to further increase the model accuracy—, while keeping the optimal growth hypothesis as the main driving force of our FBA model.
However, Goldstone et al. place a greater emphasis on the group's motivation in minimizing the total length of the trail system and using the common tracks as the main driving force of the collective path formation.
It is shown that only the radial gradient can cause separation of mixture and thermal diffusion caused by radial temperature gradient performs as the main driving force of thermoacoustic separation.
As a main driving force of electric vehicles (EVs), the loss of in-wheel permanent-magnet synchronous motor (PMSM) direct drive system can seriously affect the energy consumption of EVs.
The SEM examination of the dendron 14 revealed the formation of long extended and entwined nanofibers via π-stacking interactions, occurring between the phenyl substituents, as the main driving force of the intermolecular self-assembly, while dendron 12 formed interesting nanorod aggregations with a well-defined rectangle structure.
ITC studies suggested entropy as the main driving force of complex formation, meaning that hydrophobic interactions are the major forces governing the efficient interaction between the two partners.
Some studies indicated the expansion of oil palm plantation as the main driving factor of deforestation in this province (Boer et al. 2012; Koh et al. 2011).
To confirm electrostatic interaction as the main driving force of POM HSA binding, further experiments were performed using differentially charged POMs and applying acidic pH values.
In fact, obesity has been shown as a main driving factor of changes in the gut microbiome between lean and obese twins where, despite different microbe assembly, a core microbiome exists and divergence from it leads to a pathological state (ie, lean vs obese).
