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Therefore, both nucleosome dynamics as well as local changes in chromatin organization, including introduction and/or removal of covalent DNA and histone modifications, at genes with a key role in cell proliferation, are of primary relevance.
The mutation of this single surface residue appeared to have produced pronounced, long-range as well as local changes.
Because interactions as detected by DamID require at least transient physical contact of the Dam-Lam protein with the chromatin fiber, we interpret changes in DamID signals as local changes in the molecular contact frequency between the NL and the probed genomic locus.
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Particularly, combining the feature sets that are invariant to global variations as well as to local changes of face images would be an effective approach to achieve an optimal face recognition system.
Ligand binding and catalysis require the precise alignment of residues from both subunits; this is very sensitive to relative motion of the subunits as well as to local changes, which underlie the modes of allosteric regulation.
As such, local changes in the electromagnetic structures seem to change the whole structure.
As such local changes are essentially independent of NP concentration, some of the limitations of systemic injections noted above may be relaxed.
As a consequence, local changes in metabolite concentration local perturbations in these networks will propagate throughout the entire network.
Voronoi diagrams were also calculated from the center-of-mass of the molecules in the top and the bottom layers, so as to highlight local changes in the structure, especially around the defects.
Nonetheless, these same animals were just as able as controls to flexibly track local changes in reward likelihood of the currently chosen option when the identity of the highest rewarding stimulus stayed the same.
So as to examine more closely local changes in response to a change in inlet conditions, experiments were also performed with a short 5 mm thin-slice of DOC (o.d. = 106 mm).
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