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And while both candidates flatter themselves by suggesting that they have the right prescription for an economy as large, complex and ever-changing as this country's, there are stark differences in their approaches.
As a result, these viruses exist within their hosts as large, complex and heterogeneous populations, comprising a spectrum of related but non-identical genome sequences [ 5- 8].
RNA viruses have high mutation rates and exist within their hosts as large, complex and heterogeneous populations, comprising a spectrum of related but non-identical genome sequences.
Application of the single-molecule real-time sequencing (SMRT) platform produced by Pacific Biosciences to small microbial as well as large complex eukaryotic genomes demonstrated the possibility of considerably improving genome assembly quality [ 1- 4].
Even small policy adjustments that are based on early evidence from evaluations can substantially influence developments in a programme as large, complex, and ambitious as introducing nationwide electronic health records.
The latter would, however, explain some of the modularity of the changes in expression patterns, as large, complex genetic networks may be affected by one or a few upstream changes.
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The protein complexes having >10 subunits were classified as large complexes and complexes having less than 10 subunits were considered as small complex.
Aggregated proteins either are rapidly degraded or remain as large complexes that disrupt cell function and decrease cell viability.
In addition, desmoplakin was detected as dot-like structures in the cytoplasm; disappeared from the plasma membrane of the BCl-2-expressing cells, indicating that desmosomal structures were internalized as large complexes upon loss of epithelial polarity.
MLL proteins function as large complexes that include tryptophan-aspartate repeat protein-5 (WDretinoblastoma-bindingnding protein-5 (RBP5), and absent small homeotic-2-like (ASH2L) as core complex members, which are indispensable for the complete methyltransferases activity, plus variable additional factors [ 4- 7].
Intensive biochemical and genetic experiments by several groups over the following years have revealed that many of the core RNAi and chromatin regulatory proteins function in concert with each other as larger complexes.
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