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Still, Kuhn was undoubtedly right: paradigms must change sooner or later, as knowledge accumulates.
As knowledge accumulates about the range of normal and pathologic variation, and new test procedures are developed, the responsible interpretation of genetic test results may become increasingly difficult.
As much as knowledge accumulates on the toxicity of numerous DBPs, it appears that the toxicity of a water sample measured through the evaluation of THM levels would provide only a small fraction of the total toxicity.
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A centralized scientific information system on BNCT is being built at the INRNE with the purpose to collect and sort new information as knowledge accumulated during more than thirty years history of BNCT.
To some extent, off-target adverse effects can also be predicted based on the same binding site characteristics, as well as knowledge accumulated from decades of clinical trials and emerging inter-disciplinary systems biology [ 58].
Throughout his work Gray hammers relentlessly against the notion, first advanced in the Renaissance and reified in the Enlightenment, that history moves inexorably in a straight line, and that human nature will necessarily improve as our knowledge accumulates.
As fundamental knowledge accumulates across all of these areas, virtual approaches will, in turn, eventually become firmly anchored to experimental and theoretical databases having validated clinical predictability.
And, in the next several years, as the knowledge accumulates, I suspect that we'll need our own Seaman Knapps and Rory Lewandowskis to help spread these practices county by county.
However, future extension for genome-scale databases to include domain-level enzyme compartmentalization will be valuable as such knowledge accumulates.
The gene clusters for these natural products have been discovered in all three domains of life, and their structural diversity continues to expand as more knowledge accumulates regarding these natural products and their biosynthesis.
As this knowledge accumulates, practice guidelines, competency frameworks, policies and professional education initiatives could be updated to reflect the realities and ethics of practitioners' everyday acts of health advocacy in the pediatric context.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com