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Here, we demonstrated that endogenous Survivin had limited cytoprotectivity in the nucleus as it was prevented from reaching and interacting with its protein targets (such as the caspases) in the cytoplasm during apoptosis.
Importantly, necrosis required viral replication, as it was prevented by aciclovir.
Induction of LTP and LTD was NMDA dependent as it was prevented by the application of an NMDA antagonist (Royer and Paré 2002).
In this regard, we have identified that mouse Drp1 phosphorylation in the equivalent serine to human Ser600 was dependent on Protein Kinase A (PKA) activity, as it was prevented by the PKA inhibitor H89.
Similar(56)
"That wasn't progress as much as it was preventing a major setback".
The FDA is prevented by its rules from making any changes in cigarettes that would create a contraband market in cigarettes, just as it is prevented from banning cigarettes.
This binding is specific as it is prevented by unlabeled HB-19 with Kd value of 312 nM and 825 nM in MDA-MB-231 cells and HUVECS, respectively (data not shown).
Thus, the target mRNA cannot be translated and the level of protein is reduced as it is prevented from reaching the ribosome [ 191, 192].
But is the hunt for insurgents causing as much harm as it's preventing?
"France's intervention started out as humanitarian, and now it is preventing the rebels from advancing.
"In our opinion, as we see it right now, it is preventing competition from happening because of the strength of the financial incentive," Vestager said in April 2016.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com