Consistently, the anti-miR-221/222 antagomir treatment of established subcutaneous tumors derived from the highly aggressive PC3 cell line, naturally expressing high levels of miR-221/222, reduces tumor growth by increasing intratumoral p27 amount; this effect is long lasting, as it is detectable as long as 25 days after the treatment.
RASSF1A hypermethylation in tumours can be a relatively early event in neuroblastoma tumorigenesis as it is detectable in non-advanced early-stage tumours with high frequency.
When Tubb3-mGFP expression was discernible in only one of the BP daughters (12 of 30 cases), it showed the same onset as when it was detectable in both (Fig. 5B).
The hepatic accumulation of PPL was observed as an early response to cholestasis; it was detectable as early as 2 days post-BDL and even in a milder cholestatic mouse model lacking the hallmarks of severe obstructive injury (i.e., dietary CA administration).
In the FA model, galectin-3 expression is initially observed in both proximal and distal tubules, and thick ascending limbs as well as collecting ducts; later, it is detectable in macrophages, particularly in areas of inflammation [12].
The signal existed, as long as Red1 was detectable.
Such a modest effect is unlikely to be observable in the radial diffusion assay, although, as our results demonstrate, it is detectable in the liquid broth assay.
As expected, when wild-type DISC1 is expressed alone, it translocates to the nucleus, where it is detectable as numerous bright puncta on a more diffuse background (Fig. 2B and Supplementary Material, Fig. S6).
Thus, klotho protein is suggested as a humoral factor [ 38] and it is detectable in CSF [ 20].
As it was shown, detectable weight loss due to the fast oxygen desorption begins in these ferrites above 573 K.
