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AS is primarily a disease of the axial skeleton, but some patients have peripheral joint involvement [ 2].
AS is primarily a disease of the axial skeleton that involves the sacroiliac joints and spine [ 8].
AS is primarily caused by deletions, mutations, or imprinting errors of the UBE3A gene on chromosome 15, but 15% of AS cases have no identified genetic abnormality at this site.
In Bangladesh, As is primarily in the As+3 form, though there are reports of a significant +5 fraction in other parts of the Bengal Delta (Zheng et al. 2004).
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