18 The number of digits involved was also counted as an index of severity of those skin diseases that disproportionately involved the digital nails; major nail disease was defined as involvement of >2 nail digits, while minor nail disease involved >2 digits.
T cell activation is a multistep process involving T cell receptor engagement by antigen/major histocompatibility complex as well as involvement of costimulatory molecules.
Certain factors may worsen prognosis, such as involvement of the liver, adrenal glands, and other organs, whereas cancers limited to the lymph nodes are associated with better survival rates.
Enhancement may occur, as well as involvement of additional limbic system components and other brain regions [5].
However, several atypical presentations such as involvement of other sites and generalized involvement have been recently reported in PVB19 infected patients.
Case characteristics such as involvement of the product manufacturer in the end-of-life treatment and continuous ownership are some of the important dimensions.
Widespread vasculitis, which is defined as involvement of the skin and at least two other organs, may develop (Table 1; Figure 1) [9–15, 15, 20 23].
Figure 1 Widespread fulminant cryoglobulinemic vasculitis is defined as involvement of the skin and at least two other organs, such as illustrated by the following case.
Phylogenetic profiling is a bioinformatics technique in which the joint presence or joint absence of two traits across large numbers of genomes is used to infer a meaningful biological connection, such as involvement of two different proteins in the same biological pathway [35, 37].
A multicriteria approach on gas pipeline network problem (as opposed to a single-criterion optimization problem) was used that makes possible to generate several solutions from which the most appropriate one can be chosen based on additional analysis, such as involvement of decision-maker to improve the acceptance of managers and practitioners.
Clinically, the classical triad of purpura, weakness, and arthralgia is present in up to 80 90% of patients and may be associated with a broad spectrum of abnormalities, including other skin and joint manifestations, as well as involvement of the kidneys, digestive tract, peripheral nervous system, and salivary glands (Additional file 1: Table S2) [9–19].
