As potential confounders, we initially considered age (as a continuous variable), current smoking status (yes/no), abstinence time (as continuous or categorized into 0 2, > 2 4, > 4 6, > 6 days), BMI (as continuous), and levels of testosterone, SHBG, FSH, LH, estradiol, and inhibin B in serum and the testosterone:SHBG ratio.
Justifications for considering CTCF as a non-canonical TF Initially considered as a canonical TF, CCCTC-binding Factor (CTCF) shows similar genomic distributions with TFs such as STAT1 and NRSF [ 51].
MRC score as a measure of dyspnoea was initially considered as a predictor of fatigue.
Autophagy, a critical homeostatic mechanism, was initially considered as a cell survival mechanism as it protected cell through nutrient shortage.
In addition, two samples, initially considered as BPH, but finally diagnosed as harboring PIN lesions were positively stained for membrane testosterone binding sites, indicating the potential diagnostic usefulness of membrane testosterone binding sites identification and/or measurement.
As p21 inhibits proliferation [8] and acts as one of the major transcriptional targets of p53 [7], it was initially considered as a potential tumor suppressor.
Finally, in 1957, cutaneous lesions on five New York butchers initially considered as possible anthrax were subsequently diagnosed as pyoderma caused by staphylococci, streptococci, or both (Epi-Aid 1958-16).
Age was initially considered as a continuous variable and then as a variable with five levels (that is, <50, 50 to 59, 60 to 69, 70 to 79 and ≥80 years).
Final data to be analysed (indicated as " B. emersonii-animal shared sequences", " B. emersonii-plant shared sequences" and " B. emersonii-animal-plant shared sequences") were obtained after their filtration against species not included in our databases (fungi, plants and animals) to remove those sequences initially considered as not found in these groups, named as contaminants in this study.
The song had been initially considered as the lead single, however, it was deemed as sounding too harsh and the record company did not want to take the risk.
