The phrase "as initial signals" is correct and usable in written English.
It can be used when referring to preliminary indicators or cues in a specific context, such as research, communication, or analysis.
Example: "The researchers identified several patterns as initial signals of a potential trend in consumer behavior."
Alternatives: "as preliminary indicators" or "as early signs".
TLRs have been implicated as initial signal transmitters under such clinical conditions [ 2, 4, 37].
ARGOS and ARL are targeted to the endoplasmic reticulum, the same subcellular location as initial signaling elements in the ethylene pathway.
Interestingly, the ethylene receptors as well as the initial signaling elements in the pathway are predominantly localized to the endoplasmic reticulum (ER) [ 4].
Upon the binding of agonists to these receptors, second messengers such as cAMP (cyclic Adenosine Mono Phosphate), arachidonic acid, DAG (diacylglycerol) and IP 3 (inositol-3-phosphate) are produced within the cell and act as amplificators of the initial signals generated by the primary binding.
For substorm onsets, earthward flowing ions appear as an initial signal of the onset in the near-Earth plasma sheet in the onset sector.
This is of particular importance in Fas/CD95-mediated signal transduction as the initial signaling events depend on protein-protein interactions [1], [4], [8].
An increased metabolic load (metabolic demand per cell or M/N) induced by partial hepatectomy serves as the initial signal inducing regeneration in the model (Additional file 1: Figure S1).
As the initial signal fades, reduction of GM3 and GD3 could contribute to a second 'burst' of IL-6 expression by alleviating the suppressive effects of these gangliosides on IL-6 itself or on TLR4.
Results in Figure 6 show that NOX4 protein expression and ROS production are clearly affected by both pharmacological inhibition and knocking down of JNK, putting this signaling pathway, and not the canonical Smad2/3 route, as the initial signal of a sequential mechanism that ends in tumor fibrosis.
Recent research has suggested that structures called centrosomes, known to be required to separate copies of the DNA during cell division, are used as a hub to integrate the initial signals that determine whether a cell should divide or not.
