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*Sirolimus or control agent given as initial immunosuppression.
A total of 11 patients were given Cyclosporin A (CsA, Novartis, Basle, Switzerland) instead of Tac (targeted trough levels of 200 250 ng/dl) and another 19 received Sirolimus (Whyeth, USA) with targeted trough levels of 6 10 ng/ml in combination with Tac as initial immunosuppression.
Similar(58)
Pneumococcal cell wall components can be observed for weeks after pneumococcal meningitis and may be a source of resurging inflammation after the initial immunosuppression by dexamethasone.
Her initial immunosuppression was ciclosporin, azathioprine and prednisolone.
Following transplantation in 2008, her initial immunosuppression had been with tacrolimus, mycophenolate mofetil and prednisolone.
The aggressive behavior of CUP may be due to initial immunosuppression and immunoediting which may allow accumulation of mutations.
Other than age, diabetes mellitus status and initial immunosuppression, the 3 patient groups were similar at baseline.
Transplant related data include type of induction therapy, initial immunosuppression, cold ischemia time, warm ischemia time and liver allograft function.
Although there were significant differences in the types of initial immunosuppression between cohorts this did not explain the differences detected.
Initial immunosuppression consisted of basiliximab 20 mg at days 0 and 4, then cyclosporine (targeted plasma level 150 200 µg/L), azathioprine (1 2 mg/kg/day) and steroids.
The impact of study participation most likely reflects a greater focus on target levels of immunosuppression and to some extent the greater use of CyA as initial CNI, although the effect remained significant in multivariate analyses accounting for baseline immunosuppression and recipient age.
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