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Among the patients discharged as initial cure, eight cases of VL relapse were identified during follow-up with a median time to relapse of 11 (IQR: 4 15) months.
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Test of cure was not routinely performed, with patients discharged as "initial cures" once they completed a full course of VL treatment and showed clinical improvement, cessation of fever, reduction of spleen size, and return of appetite at the time of discharge as per WHO descriptions of treatment response [ 15].
This study demonstrated that at a dose of 0.7 mg/kg/day for 28 days (20 mg/kg total dose), amphotericin B deoxycholate was equally as effective in the initial cure and prevention of relapses as antimonials (cure rate 62.6%%) [ 108].
Definite cure (BPK282/0 and BPK085/0) was defined as a patient with initial cure who showed no symptoms and signs of relapse at the 12 months follow-up visit.
This three-tier filtration experiment was conducted on PCFs, which were tested right after initial curing as well as after an accelerated carbonation exposure.
Presently, antibiotics such as metronidazole used to treat BV give initial cure rates of approximately 90% or better [ 6].
As of July 2012, 1439 immunocompetent primary VL patients had been treated, with an initial cure rate of 99.6%, 4 deaths (0.3%) and 1 (0.1%) defaulter.
The primary objective of this study was to investigate if supplementary lactobacilli treatment could improve the initial cure rate after vaginal clindamycin therapy, and secondly, if lactobacilli as repeated adjunct treatment during 3 menstrual cycles could lengthen the time to relapse after initial cure.
There was, however no improvement in the initial cure rate.
Although the initial cure rates were 64%%, almost all of the patients relapsed [ 103].
Surgical treatments have the highest primary clearance rates with initial cure rates up to 60 90%.
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