Genotypes at SNP and QTL from the initial breeding populations, as well as pedigree information of the last four generations in Deli and last two in La Mé, were retained to be used in the final step of the simulation (comparison of RRS and RRGS).
A second group of Spanish cultivars derived from the earliest breeding activities in Spain, remains in a distinct group close to the Asian cluster, indicating the origin for the first cultivars used as donors in initial breeding programs.
Initial breeding pairs (F0) had a defined background of approximately C57BL/6J 50%:129/SvJ 50%.
JK participated in the initial breeding of the congenic mice.
Initial breeding approximated a Mendelian distribution of genotypes on weaning.
Each of these combinations had five replicates, which had different simulated initial breeding populations.
Runs were kept only if the genetic parameters in the simulated initial breeding populations were close to the real values of the current Deli and La Mé breeding populations.
The simulation process was repeated several times from the allocation of QTL to the generation of initial breeding populations.
The initial breeding pairs of wild-type and Ames dwarf mice were obtained from The Jackson Laboratory.
The influences of the core size on the major core parameters, such as initial keff, steady keff, maximum power density, peak burn-up and burn-up ratio between breeding and ignition subassemblies are calculated and investigated.
