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The new filter stages are sufficiently fast that the post-HMM-filtering CM DP algorithms as implemented in the previous version (1.0.2) became the clear computational bottleneck.
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To verify the validity of previous estimates of genome size [ 24] k-mer analysis was used as implemented in the code kmergenie (version 1.6950; [ 37]).
Following our previous work [7 13], all computational studies were performed with the Gaussian 09 [27] series of programs with density functional methods as implemented in the computational package.
As in our previous ADMD studies, we used the AMBER94 all-atom force field [ 11] with GBSA solvation model [ 21] as implemented in the TINKER package [ 22].
Costs reflect the interventions as implemented in the trial.
The approach used was similar to the one implemented in the previous DOXA survey [ 13- 15].
Firstly, genes with top-ranked expression variations across samples, which explain most of the total variance potentially contributed by known or unknown factors (for example, the hidden cancer subtypes), were selected as "feature genes" in the initial gene selection as implemented in several previous studies [16,17].
For the purpose of SNP-based diagnostics in tall fescue, therefore, it may be more reliable to use nucleotide variants identified previously in conserved regions of the chloroplast DNA-derived gene matK and the internal transcribed spacer region of ribosomal DNA, as implemented in a previous study [ 26].
Despite this level of capability, the use of monochromatic light as implemented in previous instruments has a number of disadvantages, especially for psychophysical studies.
Contrasts to be masked were maintained at p < 0.001, whereas the inclusive mask was thresholded at p < 0.05 as implemented in previous studies (Uncapher and Rugg 2009; Joly et al. 2012).
Echo time in this case was 4.9 ms, and repetition time was 11 ms. Overall scan time for the acquisition of these sequences was approximately 19 min. The tractography method chosen was the Probability Index of Connectivity (PICo) algorithm (Parker et al. 2003), as implemented in Camino, which was used in a previous study to reconstruct the OR (Yogarajah et al. 2009).
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