On the basis of these observations we hypothesized that this modified WCST administration could be used as a criterion that, if validated, could be able to unveil different patient subgroup with different pathophysiological trajectories.
'Molecular-positive' resection margins may thus be proposed as grounds for more aggressive treatment or surveillance if validated as a broadened concept.
If validated as a drug target, it may also serve as a scaffold for designing specific inhibitors.
(Workplace organisation, if validated as a determinant of health, would also be regulated under the fair equality of opportunity principle).
If validated as a measure of RA disease severity, the CIRAS may serve as a potentially important tool in adjusting for RA severity in pharmacoepidemiology studies of RA treatment and complications using health care utilisation data.
For example, VDR [ 55], E2F3 [ 56] and CREB1 [ 57] can be easily detected in the blood and blood-based diagnostic assays can be easily developed to measure these TFs if validated as biomarkers of OC.
32– 34 If validated as a correlate of delayed clearance in vivo, standardized, high-throughput in vitro methods for measuring refractoriness of ring forms to artemisinin could be a valuable surveillance tool.
Based on these data, BCL9 may serve as a future potential biomarker if validated in a larger dataset of DCIS patients with known outcome data.
Again, the clinical implications, if validated, are significant as IAP consensus guidelines recommend surgical resection of all MCN while surveillance is reasonable for most BD-IPMN.
If validated, findings such as these may contribute to increased molecular knowledge of basic glioblastoma pathophysiology and raise the possibility of detecting metabolic marker patterns associated to early treatment response.
If validated, syndecan-1 might be useful as a biomarker to help further distinguish molecular phenotypes of ARDS.
