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The US Preventive Services Task Force guidelines rate CRC screening as "A" (strongly recommended), BC screening as "B" (recommended), and both prostate cancer (PC) and lung cancer (LC) screenings as "I" (evidence insufficient to come down in favor or against screening) [ 3].
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For example, interventions such as IV rehydration and antibiotics for urinary tract infection, categorized as level II evidence in the Moyer study, were classified as level I evidence in our study.
These works were comprehensively evaluated in a pooled analysis that now permits to classify the prognostic significance of DTC as level I evidence.
If a randomized control trial (RCT) or a systematic review was found, the intervention was classified as level I evidence.
This would be considered as level I evidence that intervention X works for condition A (Table 1).
It is practically and ethically difficult to mount cluster randomised controlled trials (cRCTs, regarded as Level I evidence) in this area.
Table 1 lists the interventions that qualified as level I evidence, based on the finding of at least one RCT or SR.
In the absence of such a trial, many would also regard a high quality systematic review and meta-analysis as level I evidence.
I don't want to be jeered as I give evidence.
Twenty-six articles (<1% of abstracts initially screened), which consisted of 25 randomized controlled trials and 1 meta-analysis, were rated as having level I evidence.
It's also as much evidence as I need to win this argument.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com