When the genes on the recurrent ICNV regions were considered as background, the global drivers were 4.2 (P < 0.0055) and 3.5 (P < 0.003) times more likely to be in V1 and V2, respectively, and the local drivers are less significantly enriched for the signatures.
At the same time, novel ways of linking local case studies with global drivers and feedbacks as determinants of land use decisions and impacts are required.
The global drivers dictating the rhino horn supply chain such as human trafficking and other socio-economic factors cannot easily be captured in a model of causal certainties.
First, global drivers can overshadow local drivers in the management of common pool resources such as river basins management and agriculture.
What are the global drivers of identity policies?
We assessed whether V1 and V2 signatures are significantly enriched in different gene sets including the global drivers, the local drivers, the drivers (global and local), the non-driver genes and the genes not on the recurrent regions (nonRR).
For the genes in the recurrent regions of amplification (RR Gain), we identified 44 global drivers and 24 local drivers.
Also the global drivers are most likely to be siRNA hits in both V1 and V2, followed by local drivers and non-drivers.
Other known breast cancer gene target such as ERBB2, E2F1 and MTDH are in the global driver list.
