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As further exploratory analyses, hypothesised relationships between specific disease categories and individual items on the RCS were also examined, as well as interactions between cognitive and physical disability as disease category predictors.
Sensitivity analyses included evaluation of the primary endpoint associated with linagliptin versus total comparators in pre-specified subgroups based on age, gender, race, and use of rescue medication, as well as further exploratory subgroups based on occurrence of hypoglycaemia and Framingham 10-year CV risk score.
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As a further exploratory step, we also used a spline term corresponding to distance under the conditional likelihood framework [ 23, 24].
As appropriate, further exploratory analyses were performed (Pearson's correlations between concentrations of investigational products: genistein, phylloquinone, 25(OH D and different efficacy and safety end-points), as well as stepwise regression analysis for determination of predictors of BMD change.
As a further exploratory assessment, we went on to specifically evaluate the tissues of initially low ADC (the proportion of the tumour with ADC values lying below the 25th percentile point of the ADC histogram – AUClow), representing the most restricted and probably the most cellular part of the primary tumour.
We therefore included these variables as potential confounders in the initial analyses, but conducted further exploratory analyses to look for evidence of effect modification.
Further exploratory analyses (data not shown) indicated that SES might be serving as an indicator for access to PCPs and orthopaedic surgeon availability.
Nevertheless, elementary descriptive analysis as an output of disease mapping can be a source of new leads for further exploratory analyses.
As presented in additional files (Additional files 1, 2, 3 and 4) we performed further exploratory analyses investigating early CTC-dynamics from q0 to q1.
The EAC also conducted further exploratory analyses.
Three further exploratory analyses were performed.
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