Agreeing, disagreeing, or unique KEGG and EFICAz annotations, as well as EFICAz assignments for hypothetical proteins can also be selected and retrieved.
We have identified a number of genes specific to this genome (Additional file 2: Table S4), including functionally annotated single-copy genes, as well as genes coding for hypothetical proteins and paralogs of known Wolbachia genes, and these should be targets for further research.
A majority of the unique genes, in all species, were annotated as coding for hypothetical proteins.
There are 11 812 sequences from T. cruzi in GeneDB that have been annotated as coding for hypothetical proteins.
About 6% of the ORFs did not match any sequence stored in the three databases and are thus classified as coding for "hypothetical proteins".
Expression of 121 genes annotated as coding for hypothetical proteins were altered in response to the antibiotics (Additional file 1, supplemental table 1).
In addition, homologs of this gene, all still defined as "coding for hypothetical proteins" in public databases, were found in other fungal ascomycetous and plant genomes.
Homologs of this gene, all defined as "coding for hypothetical proteins" in public databases, were exclusively found in ascomycetous fungi and in plants.
In addition, the transcriptome analysis highlighted numerous genes with unknown function, annotated as coding for hypothetical proteins [see Additional file 2].
The game could possibly be useful as an introduction or complement to an individual CBT, as a training for hypothetical reasoning, or as a stimulator easing collaborative discussions between patients and caregivers.
