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In brain, HFS elicited IR as evidenced by a significant decrease in tyrosine phosphorylation of insulin receptor and an increase serine phosphorylation of IRS-1.
Treatment of rats with the PI3K inhibitor abolished the effect of KGF on PDX1 expression as evidenced by a significant decrease in the number of PDX1 positive ductal cells in the pancreas of 2-day-old KGF treated diabetic pups pre-treated with wortmannin, compared to the KGF treated group, while this treatment did not alter the basal number of PDX1 expressing ductal cells (Figures 9A and 9B).
Testosterone inhibited both bone formation (as evidenced by a significant decrease in double-labeled surface and serum osteocalcin level) and bone resorption (as evidenced by a significant decrease in RANKL mRNA expression), so bone remodeling was halted.
Knockdown of GPER significantly reduced the ability of both estrogen and G-1 to stimulate FOXO3-GFP translocation (Fig. 4a), as evidenced by a significant decrease in the percentage of cells with cytoplasmic FOXO3-GFP localization.
As a whole, students were less risk averse after completing the MathBench modules, as evidenced by a significant decrease in the frequency of "I don't know…" responses between the pre- and the posttests (F1196 = 80.578, p < 0.0001).
Orthostat-L™ significantly reduced donor site pain over the first 12 hours postoperatively as evidenced by a significant decrease of the AUC in both VAS (p = 0.0366) and Wong Baker FACES pain score plots (p = 0.0024).
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In mice lacking SV2B, synaptic transmission at the synapse between photoreceptors and bipolar neurons was decreased, as evidenced by a significant reduction in the amplitude of the b-wave in electroretinogram recordings.
In addition to distorted morphology, there is also a significant decrease in the A16 group of dopamine neurons in Prokr2 null mice, as evidenced by a significant reduction in TH-positive neurons in the periglomerular layer.
We also showed that PF-03084014 decreases the Notch pathway in the sensitive tumour CRC021 as evidenced by a significant reduction in cleaved Notch activity.
Tolerance manifested as a decrease in seizure threshold to near-control values, while withdrawal hyperexcitability was evidenced by a significant decrease in seizure threshold below the control value.
Increasing the availability of intracellular NAD+ favored the production of more oxidative metabolites, as evidenced by a significant increase in the acetoin production, while decrease in the production of lactic acid and ethanol.
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as evidenced by a significant rise
as evidenced by a significant accumulation
as reflected by a significant decrease
as shown by a significant decrease
as noted by a significant decrease
as evidenced by a monotonic decrease
as evidenced by a significant amelioration
as visualised by a significant decrease
as evidenced by a small decrease
as evidenced by a significant development
as evidenced by a significant improvement
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com