In severe models (Smn −/− ; SMN2 and Smn −/− ; SMN2 Δ7) this is evidenced by a dramatic decrease in the factors regulating myogenesis.
Under anaerobic chemostat conditions, NADH availability increased from 2 to 3 mol NADH/mol glucose consumed and the production of more reduced metabolites was favored, as evidenced by a dramatic increase in the ethanol to acetate ratio and a decrease in the flux to lactate.
For example, overexpression of the NAD+-dependent formate dehydrogenase in E. coli resulted in a significant redistribution of metabolic fluxes, as evidenced by a dramatic increase in the ethanol-to-acetate ratio and a decrease in the flux to lactate (Berrios-Rivera et al. 2002a).
Under anaerobic conditions, the production of more reduced metabolites was favored, as evidenced by a dramatic increase in the ethanol-to-acetate ratio.
Coaching is estimated to be a $2 billion global industry that is rapidly growing, as evidenced by a dramatic increase in coaches, professional coaching organizations and coaching-related research.
When the coated particle was exposed to light, the shell remained intact while the core degraded as evidenced by a dramatic change in diffusion coefficient of fluorescent beads immobilized within the core.
Subsequent treatment with 46 (30 mg kg 1) resulted in a rapid reversal of neuromuscular block as evidenced by the dramatic decrease in time required for spontaneous breathing and a return to a train-of-four (TOF) ratio of 0.9.
Tg+ sick late (disease grade ≥3) mice continued to have a dramatic infiltration of mononuclear cells (Fig. 3D), and also exhibited a significant loss of sciatic nerve tissue, as evidenced by a decrease in tissue diameter.
Compared with PBS-treated wounds, 2.0 mg ml−1 FMOD-treated wounds exhibited improved gross appearance (as evidenced by a decreased Visual Analogue Score; b).
The TAD borders appeared partially disrupted as evidenced by an increase in inter-TAD contacts and a decrease in the contact density within TADs (Fig. 3a, lower panel).
