Sentence examples for as essentiality from inspiring English sources

Finally, we studied the variation in operon conservation as a function of genome size and relevant biological traits such as essentiality, gene expression and protein concentration.

As essentiality and redundancy of genes interplay with expression and fitness effects, we set out to understand this interplay using WGD pairs.

Generally, the biomass equation is set as the objective function for the simulation of optimal growth and other model evaluations such as essentiality study.

In addition, the gene expression profile used in the study was confined to embryogenesis in D rosophila melanogaster (Manak et al. 2006), and the GO annotation was incomplete; other types of phenotypic information such as essentiality were not considered.

For example, similar to reports of significance in yeast PPI networks [ 24, 34, 35], node degree (the number of other proteins that a protein is connected to) in bacterial co-conservation networks is predictive of broad functional categories, such as essentiality.

Finally, we calculated the operon conservation index for A (OCIA) as follows: We also computed OCI values for subsets of pairs of genes according to the variables of interest such as essentiality, gene expression, and protein concentration (supplementary table S1, Supplementary Material online).

This situation was defined as conditional essentiality, as the enzyme becomes essential when some substrates are not available in the medium.

We show strong positive correlations between gene connectivity within the whole network and gene essentiality as well as gene sequence conservation.

Although it seems likely that both protein essentiality as well as the expression level of the mitochondrial genes should be higher compared to their bacterial counterparts, we are not aware of any experimental studies corroborating these suggestions.

More generally, the observation that entire complexes appear essential, henceforth referred to as modular essentiality, indicates that phenotypes can be associated with whole complexes and are not restricted to individual genes.

Two representative perspectives on this definition are the narrow essentiality criteria of no observable growth in minimal media and the broad essentiality criteria used by Orth et al. The narrow glucose essentiality criteria treat as essential those Baba et al. and Yamamoto et al. gene deletion mutants with OD600 ≤ 0.005 after 24 and 48 hr growth on glucose minimal media.