Sentence examples for as essential role from inspiring English sources

IL-6 is a pleiotropic cytokine with effects on a number of cell types, including B cells, where it plays as essential role in plasma cell differentiation and survival.

As essential roles for all of the Ccm proteins have been established, it was a surprise to find a variant system that had significant differences.

However, whether DUSP6/ MKP- 3 induction represents a negative-feedback control or an example of regulated cross-talk between two intracellular signalling pathways is controversial, as essential roles have been proposed for both ERK MAPK and PI3K signalling in regulating DUSP6/ MKP- 3 expression [ 10– 15, 15].

Experimental and epidemiological evidence highlights the involvement of IGF-I system in different malignancies (Khandwala et al, 2000), as well as an essential role in angiogenesis along with VEGF (Smith et al, 1999).

The involvement of the ErbB receptor tyrosine kinases in human cancer, as well as their essential role in various physiological events during normal development, have motivated a high interest in this receptor family.

Cytokines mediate bone damage by driving the differentiation and activation of the bone-resorbing cell, the osteoclast [33], as well as playing an essential role in immune cell development and immune-regulation.

Schools may serve as an essential role in early identification and could be able to provide psychological interventions for these children.

Although there have been abundant studies reporting that miR-15b may serve as an essential role in the development and progression of human tumors, the effect of miR-15b in mediating glioma cell growth remains unexplored.