The phrase "as early replicated" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to something that has been replicated early in a process or study, but the phrasing is awkward and unclear.
Example: "The findings were significant, as early replicated studies showed consistent results."
Alternatives: "as previously replicated" or "as initially replicated".
Using anti-BrdU antibodies to detect BrdU incorporated in late S phase of the cell cycle, we found that one X chromosome was entirely late replicating, while the other showed only the heterochromatic part as late replicating, and the euchromatic part as early replicating (more than 50 metaphases were examined; Fig. 5B).
It is also known that Doc exerts its killing activity only on the early, replicating granulopoiesis compartments, as it is a cell-cycle-specific drug (Jordan and Wilson, 2004).
The results of HCV ssRNA in situ hybridization and dsRNA immunofluorescent staining showed that HCV genome started to replicate as early as 12 hpi, and accomplished its genome replication steps steadily throughout the course of infection.
None of four deletions, which together covered all of the non-R1 portion of the THF, was sufficient to permit the remaining fragment to replicate as early as does region R1 by itself.
Alu-mediated deletions have been shown to occur in regions with a high GC content (∼45%) [ Sen et al., 2006] and a high GC content was associated with early replicating regions as well as an increased frequency of DNA breaks in neuroblastoma translocations [ Stallings, 2007].
In contrast, low, physiologically relevant doses of estrogenic chemicals (DES and BPA) fed to pregnant mice induced up-regulation of prostatic androgen receptor ligand binding activity in male offspring as early as PND3; this observation was replicated in organ culture of fetal mouse prostate treated with 0.1 pg/mL DES or 50 pg/mL BPA (Gupta 2000).
In contrast as early-replicating loci are more interactive52,53, DNA breaks occurring in regions replicating in early S-phase are more likely to result in trans translocations.
These data suggests that in TS and XEN cells, many developmental regulator genes remain 'accessible' - as reflected by the prevalence of early replicating loci - similar to that reported previously for ES cells [ 19].
Previous reports have shown that inhaled LVS infects preferentially airway macrophages and dendritic cells, as early as 1 h after infection, and continues to replicate within them [7] [8].
We found that in two different biological replicate experiments Pitx2 was activated as early as 2 hours after Alk4* de-repression (removal of SB).
