We propose that rather than dedifferentiation of SSCs as earlier postulated, it may be possible that the VSELs per se expand to give rise to ES-like colonies in vitro [ 20].
Thus, our observation of an early Las-mediated up-regulation of a CAP 160 protein and a chloroplastic light/drought-induced stress protein suggest attempts by the host plant to mitigate a possible disruption of the water balance by Las via a disrupted transpiration stream as earlier postulated.
Because a hh gene has recently been identified in cnidarians, the most parsimonious explanation for these nematode specific gene families is that they are evolutionarily derived from a hh gene in early nematode evolution [ 12], and that the loss of the Hog domain in many of the genes is a secondary event, as earlier postulated [ 11].
The KRAB domain, early postulated as a protein-protein interaction domain [ 8], has been shown to interact with the RBCC domain of TRIM28 (tripartite motif-containing 28, also known as KAP-1, KRIP-1, TIF1β; reviewed in [ 20]).
The importance of strain energy density and in particular the distortional part of it relative to material failure was understood, conjectured and postulated, as early as in the era of Maxwell (1937) and others (Hencky 1924; Huber 1904).
In experimental studies, adult S. haematobium worms have been shown to suffer immune mediated attrition and reduction of fecundity [ 4- 6] and, as early as 1934, Fisher postulated that the epidemiology of human schistosome infections reflects these immunological processes [ 7].
An association between occupational exposures of inhaled particulates and autoimmunity was postulated as early as 1914, when Bramwell (1914) reported increased frequency of diffuse scleroderma (SSc) in stone masons.
The earliest postulated Kannada writer from this dynasty is King Durvinita of the 6th century.
This decay mode is especially important for astatine; as early as 1950 it was postulated that all isotopes of the element undergo beta decay.
As early as 1863, Virchow first postulated that cancer originates at sites of chronic inflammation, in part based on his hypothesis that some classes of irritants causing inflammation also enhance cell proliferation [ 13].
