Prolonged incubation probably results in degradation or ejection of VHCDR3 by the cells, as documented by the rapid decrease of MFI and percentage of positive cells at 72 h (Fig. 2A).
Mean national blood Pb levels have decreased dramatically over the past 30 years, as documented by the third National Health and Nutrition Examination Survey, Phase 2 (NHANES, 1991 1994) (CDC 2000; Pirkle et al. 1998).
After four weeks of stress, more than 90% of stressed rats showed signs of anhedonia as documented by a decrease in sucrose preference compared to nonstressed controls (i.e., <50% of sucrose consumption compared to nonstressed controls).
The significant prevention of proteoglycan loss from the epiphyseal growth plate by HA at this time point may be due to the clear anti-arthritic effects of HA, as also documented by the significant decrease of acute inflammation on day 8 (Fig. 6a).
As expected, forced expression of mPGES-1 in LNCaP cells promoted an increase in PGE2 production, cell growth and development of the mesenchymal phenotype as documented by E-cadherin decrease (Supplementary Figure 4B, C, D and E).
These injuries, as documented by decreased ligament strength, may potentially lead to altered facet loading patterns causing excessive synovial fold and facet articular cartilage compression.
They have shown more advanced left ventricular remodeling in a model with cardiorenal failure as documented by left ventricular hypertrophy, decreased capillary density and increased fibrosis.
Effects on bone resorption start within 12 h, as documented by a rapid dose-dependent decrease in urinary and serum N-telopeptide levels.
The Mecr transgenic animals have impaired mechanical heart function in vivo as documented by (i) echocardiography and (ii) decreased physical performance in exercise endurance tests.
