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Treatment changes, as well as discontinuation of medication at any time after baseline, were permitted and did not lead to discontinuation of the respective patients.
De-escalation was defined as discontinuation of an antimicrobial agent or change of antibiotic to one with a narrower spectrum once culture results were available.
Understanding the natural history and good response to corticosteroids of most ipilimumab ocular irAEs is important for management, as discontinuation of ipilimumab therapy is reserved for severe or life-threatening irAEs.
Patients responding to cART with a CD4+ count >100 cells/µl after 9 months of cART were dropped from intervention's cycle, as discontinuation of cryptococcosis prophylaxis during cART is considered in patients with CD4+ count >100 cells/µl [17], [18].
The compliance of < 90% defined as discontinuation.
Issues such as discontinuation of Mirena will be an important factor.
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Subjects lost to follow-up (n = 6) were reported as discontinuations.
Total AEs, serious AEs, and infusion reactions as well as discontinuations for AEs were most frequent during the first 26 weeks.
We also found that AEs as well as discontinuations for AEs most often occurred during the first 26 weeks of treatment.
Two patients were recorded as discontinuations despite completing the study as scheduled: 1 due to an ocular adverse event and 1 due to other reasons (non adverse event-related), both occurring at the end of the study.
Patients who died withdrew informed consent or did not discontinue rivaroxaban were censored at that specific date or the last date of follow-up contact, but were not counted as discontinuations.
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