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If the only option is a 4- exo process, as in the case of the homoallylic alcohol 78, the reaction has been found to take a different course (Scheme 24).[ 40] Here, the C=C bond coordination to PdII (as described in Scheme 21) becomes unproductive, as cyclization to produce the corresponding oxetane 79 would be too high in energy.
Compounds A1 A54 were prepared as described in Scheme 1.
Eighteen target compounds were synthesized with commercially available 1, 3 or 2 (synthesized in our laboratory) [13, 14] as the starting material as described in Scheme 1.
The resulting oxindoles 16 and 17 were used to synthesize the desired products 6 and 7, respectively, as described in Scheme 1.
Similar to the preparation of 3a [12], the rest matrinols 7a i were obtained by the LiAlH4 reduction of the corresponding methyl matrinate 6 as described in Scheme 1 with yields of 75 85%.
To remove the user's explicit intervention of specifying the depth of the tree cut and separation, our pruning method tested four different depths and chose the depth where MSQb was the highest and the fewer in the sizes of clusters as described in Scheme 2 and Fig. 3.
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As shown in Table 2, we categorized these 4 parameters using a low-medium-high rating scheme as described in the Methods.
To address this point, truncated CENP-C proteins labelled with HA- or FLAG-tag, as described in the scheme in Figure 4, were co-transfected in HEK-293 cells.
Murine breast cancer cells were also implanted in the experimental mice as described in the scheme shown in Fig. 1a.
H NMR spectra indicated that ester bonds connected to cross-linkable methacrylate groups replaced approximately 50% of available P OH groups after the esterification described in Scheme 2. As shown in Table 1, LCSTs decreased with increasing GMA incorporation.
As described in the first scheme, we define the system state at time t as follows n → ( t ) = ( n PU i ( t ), n SU i ( t ), n SU − i ( t ), i = 1, …, N, (13).
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