The construction of colostomy is associated with decreased physical and psychological well-being as well as decreased quality of life.
74– 76 Caregivers of these individuals suffer similar consequences, such as decreased quality of life, medical and psychiatric morbidities, 76– 79 as well as increased risk of mortality.
6 As a consequence, many suffer from macro- and microvascular diabetic complications like coronary heart disease, stroke, blindness, nephropathy, and peripheral neuropathy, as well as decreased quality of life, decreased functional status, emotional distress, and elevated death risks.
If recognized and treated, depression is often reversible, but if left untreated, depression may result in the onset of physical, cognitive, functional, and social impairment, as well as decreased quality of life, [ 38] and higher mortality [ 39].
There are increasing concerns in relation to serious adverse effects such as decreased quality of life, accelerated cognitive decline, and even stroke and death by the use of antipsychotics (Ballard et al., 2009; Brown et al., 2012).
The actual economic cost of injury is probably much higher, because the above figures do not include the cost of life and work years lost secondary to injury or death, the loss of property, and indirect costs such as decreased quality of life and mental health concerns.
All these characteristics should be continuously monitored throughout the RTRS development cycle, to provide decision support and detect the first signs of low or decreasing quality as the system design evolves.
Anemia is one such risk factor, and is associated with CVD [ 10], chronic diseases [ 11, 12] and mortality, as well as a decreased quality of life in patients with chronic disease [ 13- 16].
Several studies show that fear of symptoms and behavioral pattern of control and avoidance, is associated with decreased quality of life as well as worsening symptoms [ 54, 55].
However, such approaches are not as effective and result in decreased quality of assemblies when the two multiplicity distributions of erroneous and error-free k-mers are not separable using a simple threshold.
In the future, stratified analysis of types of OML should be considered as chronic OML has proven to decrease quality of life [ 41].
