Alternatively, CpG dinucleotides in viral RNA may be selected against as they may serve as targets for currently uncharacterized pathogen recognition receptors couple to interferon or other cell defence pathways [ 12].
This size range is typical of C/D snoRNAs [ 23], but none of the candidates have canonical CD boxes, indicating that these CRUFTS expressed in the SK-N-AS cell line are not snoRNAs, but belong to currently uncharacterized ncRNA genes families.
As we move into the post genome-sequencing era, an immediate challenge is how to make best use of the large amount of high-throughput experimental data to assign functions to currently uncharacterized proteins.
These included numerous transposases, proteins from IS elements, and proteins of unknown function (CDSs conserved in other species with currently uncharacterized function).
We also highlight biological processes likely to be performed by currently uncharacterized genes (e.g. autophagy).
The iGM strains developed here are expected to facilitate these studies and can be used as a resource for detailed characterization of the mechanism of Sec insertion and to assign functions to currently uncharacterized trans-acting factors that influence Sec incorporation.
Significantly, the division into subfamilies allows the identification of currently uncharacterized subfamilies that can subsequently be analyzed biochemically and structurally to potentially unveil new activities.
However, these and other eukaryotic phyla show a range of other dinucleotide frequency biases with currently uncharacterized underlying mutational or selection mechanisms.
We also found an additional 1,236 bona fide intronic regions that give rise to currently uncharacterized short RNA transcripts satisfying the above constraints.
A currently uncharacterized E. coli gene, ybiU (b0821), was identified by BLASTp as a candidate gene for this reaction, providing a testable hypothesis for the function of this gene.
A new and currently uncharacterized PhaZ3 enzyme is now referenced.
