We interestingly observed that some microRNA targets (e.g., CCNA2, PTTG1, CDK1, CCNB2, CDC25B, CCL7, MAPK12, and ESPL1 from the temporal up-pattern genes and CYP2F2, CYP3A11, and CYP2C50 from the temporal down-pattern genes) can act as core targets connected with multiple significant pathways from non-microRNA targets.
SLC2A3 was identified as a core target of miR-106a in GBM cells.
Overall it appears that functional analysis of differentially expressed genes and proteins tends to identify core target pathways, such as metabolism, while the anaylysis of topologically significant proteins reveals key signaling processed activated in androgen-stimulated cells.
These properties are as core as core can be.
MS: Our core target audience is 18-30 year olds globally.
Given that women increasingly report using drugs to lose weight, substance abuse treatment programs must include body image, weight, eating pathology, and health knowledge as core intervention targets.
But Knight Frank predicted that wealthy people this year would expand their searches to include European cities previously thought to be too economically distressed: Milan, Madrid, Barcelona and Dublin, which will join Munich, Berlin, Zurich, Geneva and Vienna as "core European targets".
These findings suggest that these conserved chromatin modification factors regulate, directly or indirectly, the same core targets as LIN-35 and that their normal function is antagonistic to that of LIN-35.
The company's brief sets out core targets, such as diverting 98% of demolition waste from landfill and 96% of construction waste.
This would deprive Republicans of the ability to focus attention on one of their core targets — Big Government — as a way to avoid grappling with other issues, such as jobs and long-term middle class economic security, immigration, guns, and perhaps even climate change.
